Computational & Statistical Systems Biology Laboratory
@ Cardiovascular Research Institute, National University of Singapore
Our laboratory develops computational and statistical solutions for the analysis of high-dimensional molecular data in various contexts of biomedical research. These tools are motivated by a wide range of research topics, including
- Integration of multiple -omics data sets towards biologically sensible interpretation of molecular features and robust outcome prediction
- Analysis of untargeted and targeted mass spectrometry (MS) data for proteomics and metabolomics
- New statistical approaches for proteogenomic analysis
- Interactive data visualization and exploration of high-dimensional data
CSSB Laboratory also provides next generation sequencing (NGS) and MS data analysis support for basic scientists and clinical investigators through Centre for Systems Biology, NUHS. Our collaborative work includes exome sequencing, epigenetic profiling, transcriptomics, proteomics and metabolomics/lipidomics data analysis.
To see examples of our work, check out the CSSB LAB GitHub page!
5 October 2019: Michael Washburn at Stowers Institute and I are editing a special issue on Computational Approaches in Multi-omics Analysis in Molecular Omics. Consider contributing to the special issue!
26 September 2019: Check out our MetaboKit tool for untargeted metabolomics analysis using data dependent and data independent acquisition modes of mass spectrometry!
13 September 2019: A new informatics approach to explore prognostic potential of whole exome sequence data with a protein-centric view is available - Gene-to-Protein-to-Disease (in review, see BioRxiv).
09 July 2019: Our paper on a supervised classification method with multi-omics data integration on biological networks, called iOmicsPASS, is available at npj Systems Biology and Applications.
Principal Investigator: Hyungwon Choi
Computational & Statistical Systems Biology Lab
Cardiovascular Research Institute
Department of Medicine, Yong Loo Lin School of Medicine
National University of Singapore
Email: hwchoi [ at ] nus.edu.sg
HC is an editorial board member at Molecular Omics -- feel free to discuss submission of your manuscript.